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Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 166-174 doi: 10.1007/s11684-014-0334-2

Abstract: Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA

Keywords： direct-acting antiviral (DAA)     nucleotide polymerase inhibitors     protease inhibitors    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract: efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitis B, long-term therapyhas been recommended due to the high frequency of off-therapy viral DNA rebound and disease relapse.activity of intrahepatic covalently closed circular DNA (cccDNA), particularly among patients receiving NA therapy

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 158-165 doi: 10.1007/s11684-014-0340-4

Abstract: The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimesterIn order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancyand after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral

Keywords： antiviral therapy     Caesarean section     cirrhosis     hepatitis B     immunoprophylaxis     mother-to-child transmission    

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Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 658-666 doi: 10.1007/s11684-019-0707-7

Abstract: Direct acting antiviral (DAA) treatments may reduce the elevated α fetoprotein (AFP), but data on how

Keywords： chronic hepatitis C     α fetoprotein     direct acting antiviral treatment     cirrhosis    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, doi: 10.15302/J-FASE- 2021390

Abstract: NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant / antiviral in the greenhouse / field evaluation / l-trp-NCA / synthesis optimization    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: Their potent antiviral properties indicated the prospect of new drugs.

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG

Frontiers of Agricultural Science and Engineering   Pages 110-119 doi: 10.15302/J-FASE-2021390

Abstract: NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant     antiviral in the greenhouse     field evaluation     L-trp-NCA     synthesis optimization    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokines and cytokines have a critical function in the innate immune responses against virus infections. The ability of a rabies virus (RABV) to induce the expression of chemokines and cytokines can lead to viral clearance from the central nervous system (CNS), whereas the ability to evade such expression and activation contributes to virulence and pathogenicity. In this review, the crucial contribution of chemokines/cytokines to clearing RABV from the CNS is discussed, including recruiting leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immune cells that are essential for viral clearance. In addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptive immune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 603-622 doi: 10.15302/J-FASE -2021397

Abstract: Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection hasThese antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeuticSpecific attention is given to the antiviral mechanisms of the molecules along with their integrative

Keywords： antimicrobial proteins / antiviral profiling of bacteriocins / antiviral therapeutics / immunomodulation    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, althoughThese unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapy

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 165-172 doi: 10.1007/s11684-012-0196-4

Abstract: and intensity-modulated radiation therapy, proton therapy has yielded more promising outcomes in localCarbon therapy in Japan showed even more promising results than proton therapy.The non-invasive nature of particle therapy affords more patients with chances to receive and benefitParticle therapy is gradually getting attention from the oncology community.However, the cost of particle therapy facilities has limited the worldwide use of this technology.

Keywords： radiation therapy     particle therapy     proton     carbon     cancer    

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Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 318-326 doi: 10.15302/J-FASE-2015080

Abstract: Garlic ( Liliaceae) has been safely used for more than 5000 years, and research on garlic extract is rapidly increasing because of its multiple biological functions. The effects of oral administration of garlic mixture (GM, water-soluble extract) on infectious bursal disease virus (IBDV)-infected specific pathogen free male white leghorn chicken were examined through histopathological, immunohistochemical, and Western blot analyses, and enzyme-linked immunosorbent assay. The results confirmed the protective effects of oral administration of 5 mg·kg BW GM (Group GM1) on bursal lesions after IBDV infection. In particular, protein expression of IBDV in the bursa decreased in Group GM1, indicating that GM administration decreased IBDV replication in the bursa. Furthermore, immunoglobulin M- and A-bearing B lymphocytes significantly increased 7 days post infection in bursae in Group GM1 ( <0.01), suggesting that the oral administration of 5 mg·kg GM offers moderate protection against B cell destruction after IBDV infection. During infection, the concentration of bursal interferon gamma (IFN-g) increased and peaked in Group GM1 earlier than in Group T (IBDV-exposed), demonstrating that GM administration prompted the production of IFN-g to protect against IBDV infection.

Keywords： garlic     infectious bursal disease virus (IBDV)     antiviral effect     IgM-bearing B lymphocyte    

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Passive antibody therapy in emerging infectious diseases

Frontiers of Medicine doi: 10.1007/s11684-023-1021-y

Abstract: In addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights

Keywords： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: rationale, the intriguing question is why cancers are insensitive or not responsive to mTOR-targeted cancer therapyERK, and Mnk/eIF4E survival signaling pathways that compromise the efficacy of rapalog-based cancer therapyThese new findings may also offer us the opportunity to rationally utilize mTOR inhibitors in cancer therapy

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF.Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF wereThe efficacy and safety of targeted therapy were compared with those of other systemic therapy optionsTargeted therapy does not provide considerable advantages in efficacy and safety over other medical treatmentsstudies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Title Author Date Type Operation

Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Journal Article

Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Journal Article

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Journal Article

Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Journal Article

Passive antibody therapy in emerging infectious diseases

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article